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Doses are typically determined based on experimental design, with careful attention to accuracy and consistency to ensure reliable data

Vitamins B6, B9 and B12 are often used in combination, but to achieve tangible results, they must be administered for at least 2 years

For meningeal leukemia, the usual doses are as follows: children younger than 1 year old: 6mg intrathecally children who are 1 year old: 8mg intrathecally children who are 2 years old: 10mg intrathecally children who are 3-8 years old: 10mg intrathecally children over 9 years old: 12-15mg intrathecally For non-Hodgkin lymphoma (induction treatment / multidrug chemo regimen), the usual dose is 1000mg/m per dose IV, given on a specific day of the cycle per regimen